debian/changelog

+python-ruffus (2.8.1-4) unstable; urgency=medium
+
+  * Enable reproducible build by removing non-deterministic temporary temp
+    output (Thanks for the patch to Chris Lamb <lamby@debian.org>)
+    Closes: #916425
+
+ -- Andreas Tille <tille@debian.org>  Fri, 14 Dec 2018 11:33:24 +0100
+
 python-ruffus (2.8.1-3) unstable; urgency=medium
 
   [ Gianfranco Costamagna ]

debian/rules

@@ -38,6 +38,7 @@ ifeq (,$(filter nocheck,$(DEB_BUILD_OPTIONS)))
 	find . -name .ruffus_history.sqlite -delete
 	find . -name "*.pyc" -delete
 	find . -name __pycache__ | xargs rm -rf
+	find .pybuild -name tmp | xargs rm -rf
 endif
 
 override_dh_auto_clean: